The association between antidepressant use and depression eight years later: a national cohort study
Authors: Ian Colman, Yiye Zeng, Anushka Ataullahjan, Ambikaipakan Senthilselvan, and Scott B. Patten
Overview
Abstract (English)
Investigations of the effects of antidepressant treatment for individuals with major depression have focused on short-term outcomes in individuals that meet very specific criteria; however, there is limited knowledge about long-term outcomes associated with antidepressant use in general population samples. This study aimed to investigate the long-term outcomes associated with antidepressant use by focusing on 486 depressed adults in a prospective observational Canadian cohort in 1998/99. We used logistic regression to investigate the association between antidepressant use and depression status 8 years later. Non-random allocation to treatment was accounted for by a propensity-for-treatment model which included thirteen predictors of antidepressant use, including: severity of depressive symptoms, previous episodes of depression (from 1994 to 1997), physical health condition, social support and socio-demographic characteristics. 29% of individuals with major depression reported antidepressant use. After adjusting for propensity for treatment in 1998/99, and antidepressant use from 2000 to 2007, depressed individuals who reported antidepressant use in 1998/99 were less likely to be depressed in 2006/07 compared to those who did not report antidepressant use (OR = 0.36, 95% CI: 0.15-0.88). Amongst individuals with symptoms of major depression, those reporting use of anti-depressants at baseline exhibited improved long-term outcomes in comparison to those who did not report treatment.
Abstract (French)
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Details
Type | Journal article |
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Author | Ian Colman, Yiye Zeng, Anushka Ataullahjan, Ambikaipakan Senthilselvan, and Scott B. Patten |
Publication Year | 2011 |
Title | The association between antidepressant use and depression eight years later: a national cohort study |
Volume | 45 |
Journal Name | Journal of Psychiatric Research |
Number | 8 |
Pages | 1012-1018 |
Publication Language | English |
- Ian Colman
- Ian Colman, Yiye Zeng, Anushka Ataullahjan, Ambikaipakan Senthilselvan, and Scott B. Patten
- The association between antidepressant use and depression eight years later: a national cohort study
- Journal of Psychiatric Research
- 45
- 2011
- 8
- 1012-1018