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Résumé (anglais)

Previous studies have linked major depressive episodes (MDEs) to obesity. The association may be partially mediated by antidepressant medication use. In the current study we examine changes inweightand BMI inrelationto MDE andantidepressantusein a general population cohort. Methods Data from a Canadian longitudinal study, the National Population Health Survey (NPHS) were used. The NPHS has collected data from a community cohort since 1994 using interviews spaced two years apart. The NPHS includes the Composite International Diagnostic Interview Short Form for MajorDepression (CIDI-SFMD). Self-reported height andweight are also recorded. Linear regression was used to describe associations between weight, BMI and MDE. Results The pattern of weight change varied by age. Respondents under the age of 65 tended togainweight over time, whereas those over the age of 65 tended to lose weight. Respondents in the younger category gained more weight if they had MDE or took antidepressantmedications. However, the extent of weightgain was modest, those with MDE and those taking an antidepressant gaining an average of approximately 1 kg over 12 years of follow-up. Limitations The study used self-reported weight, which may be inaccurate. Measurements were made two years apart. The measure of MDE was an abbreviated diagnostic interview. Conclusions Both MDE andantidepressantmedicationuse are associated with a modest increase inweightin people under 65. These results may be useful for physicians and other health professionals in planning dietary andweight-management regimens for depressed patients.