Overview

Abstract (English)

Despite the prevalence of prostate cancer its pathogenesis remains unclear. Marked differences in mortality rates have been observed between countries, however, it is unclear whether the source of the observed differences is driven by underlying genetics, geographic, or social factors. This thesis investigated the impact of ethnicity and immigration on prostate cancer mortality in Canada using the Canadian Census Health and Environment Cohort. South Asian and East Asian men were seen to be at decreased risk of prostate cancer mortality, while no increased risk was observed in black men. These results affirm studies showing lower risks in Asian men; however, they contradict the previously held notion that black men are at increased risk of aggressive disease. Attempts to study the impact of immigration on prostate cancer mortality were limited by small sample sizes and missing data. Efforts to improve linkages and a longer timespan may allow for future analysis.

Abstract (French)

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