Incidence trends of conjunctival malignant melanoma in Canada
Authors: Feras M. Ghazawi, Rami Darwich, Michelle Le, Abdulhadi Jfri, Elham Rahme, Julia Valdemarin Burnier, Denis Sasseville, Miguel N. Burnier Jr., and Ivan V. Litvinov
Background Melanoma is the most common primary malignancy of the eye in adults. While the epidemiology of uveal melanoma has recently been described in Canada, little is known about the epidemiology and geographic distribution of patients with conjunctival melanoma (CM) in Canada. Methods We conducted a population-based study of CM incidence across all Canadian provinces and territories during 1992-2010 using two independent population-based registries. Results 190 patients were diagnosed with CM in Canada from 1992 to 2010. 55.3 % of these patients were men. The mean annual incidence rate of CM in Canada was 0.32 cases per million individuals (0.35 and 0.29 cases per million individuals for men and women, respectively). The incidence rates for Canadian provinces demonstrated that the eastern provinces of Nova Scotia and New Brunswick had higher age-adjusted incidence rates than the national average, with rates of 0.52 and 0.47 cases per million individuals per year, respectively. Conclusions This analysis demonstrates novel variations in CM incidence rates between different Canadian provinces. These results taken together with the data reported from the USA confirm the North-to-South geographic gradient of increasing CM incidence. This research highlights that the epidemiology of CM in North America is comparable to that of cutaneous malignant melanoma in contrast to the trends for uveal melanoma distribution.
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Rami Darwich, Feras M. Ghazawi, Michelle Le, Elham Rahme, Nebras Alghazawi, Andrei Zubarev, Linda Moreau, Denis Sasseville, Miguel N. Burnier Jr., and Ivan V. Litvinov (2020).
Epidemiology of invasive ocular surface squamous neoplasia in Canada during 1992-2010
British Journal of Ophthalmology , 657-661
Feras M. Ghazawi, Rami Darwich, Michelle Le, Elham Rahme, Andrei Zubarev, Linda Moreau, Julia Valdemarin Burnier, Denis Sasseville, Miguel N. Burnier Jr., and Ivan V. Litvinov (2019).
Uveal melanoma incidence trends in Canada: A national comprehensive population-based study
British Journal of Ophthalmology , 1872-1876
Feras M. Ghazawi, Agnihotram V. Ramanakumar, Akram Alakel, Francois Lagacé, Alex Chen, Michelle Le, Hacene Nedjar, Denis Sasseville, Elham Rahme, and Ivan V. Litvinov (2020).
Incidence of acute myeloid leukemia: A regional analysis of Canada
Cancer , 1356-1361
Feras M. Ghazawi, Elena Netchiporouk, Elham Rahme, Matthew Tsang, Linda Moreau, Steven Glassman, Nathalie Provost, Martin Gilbert, Sara-Elizabeth Jean, Osama Roshdy, Kevin Pehr, Denis Sasseville, and Ivan V. Litvinov (2018).
Distribution and clustering of cutaneous T-cell lymphoma (CTCL) cases in Canada during 1992 to 2010
Journal of Cutaneous Medicine and Surgery , 154-165
Feras M. Ghazawi, Jessica Lu, Evgeny Savin, Andrei Zubarev, Peter Chauvin, Denis Sasseville, Anthony Zeitouni, and Ivan V. Litvinov (2020).
Epidemiology and patient distribution of oral cavity and oropharyngeal SCC in Canada
Journal of Cutaneous Medicine and Surgery
Feras M. Ghazawi, Michelle Le, Nebras Alghazawi, Elham Rahme, Linda Moreau, Elena Netchiporouk, Andrei Zubarev, Osama Roshdy, Steven J. Glassman, Denis Sasseville, and Ivan V. Litvinov (2019).
Trends in incidence of cutaneous malignant melanoma in Canada: 1992-2010 versus 2011-2015
Journal of the American Academy of Dermatology , 1157-1159
Rami Darwich, Feras M. Ghazawi, Elham Rahme, Nebras Alghazawi, Julia Valdemarin Burnier, Denis Sasseville, Miguel N. Burnier, and Ivan V. Litvinov (2019).
Retinoblastoma incidence trends in Canada: A national comprehensive population-based study
Journal of Pediatric Ophthalmology and Strabismus , 124-130
François Lagacé, Feras M. Ghazawi, Michelle Le, Evgeny Savin, Andrei Zubarev, Mathieu Powell, Linda Moreau, Denis Sasseville, Ioana Popa, and Ivan V. Litvinov (2020).
Penile invasive squamous cell carcinoma: Analysis of incidence, mortality trends, and geographic distribution in Canada
Journal of Cutaneous Medicine and Surgery , 124-128