Epidemiology and patient distribution of oral cavity and oropharyngeal SCC in Canada
Authors: Feras M. Ghazawi, Jessica Lu, Evgeny Savin, Andrei Zubarev, Peter Chauvin, Denis Sasseville, Anthony Zeitouni, and Ivan V. Litvinov
Background Oral cavity cancers (OCCs) and oropharyngeal cancers (OPCs) continue to be a major source of morbidity and mortality worldwide requiring the shared effort of numerous specialists. Tobacco and alcohol consumption have long been identified as risk factors for both OCC and OPC. In addition, human papilloma virus (HPV) is gaining its position as the main causal agent for OPC. Objective The objective of this study is to analyze the epidemiology of OCC and OPC in Canada. Methods Data pertaining to the year of diagnosis, the patient’s sex, age at the time of diagnosis, province/territory, city and postal code of oral cavity, and oropharyngeal malignancies diagnosed during 1992-2010 were extracted from the Canadian Cancer Registry and Le Registre Québécois du Cancer. Results In total, 21 685 OCC cases and 15 965 OPC cases were identified from 1992 to 2010. Of those, 84.97% were oral cavity squamous cell carcinomas (SCCs), 88.10% were oropharyngeal SCCs, and both had a significant male predominance. While oral cavity SCC incidence stabilized over the study period, oropharyngeal SCC continued to increase. Oral cavity SCC incidence increased with age, while oropharyngeal SCC incidence peaked in the 50- to 59-year age group. Detailed geographic distribution analysis of patients at the provincial/territorial, city, and postal code levels identified several patient clusters. Conclusions This work highlights important epidemiological differences in trends between oral and oropharyngeal cancers, identifies high-incidence postal codes for each malignancy, and correlates incidence/mortality with known risk factors including alcohol/tobacco use and HPV infections, therefore providing a comprehensive understanding of epidemiology for these cancers in Canada.
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Feras M. Ghazawi, Elena Netchiporouk, Elham Rahme, Matthew Tsang, Linda Moreau, Steven Glassman, Nathalie Provost, Martin Gilbert, Sara-Elizabeth Jean, Osama Roshdy, Kevin Pehr, Denis Sasseville, and Ivan V. Litvinov (2018).
Distribution and clustering of cutaneous T-cell lymphoma (CTCL) cases in Canada during 1992 to 2010
Journal of Cutaneous Medicine and Surgery , 154-165
Feras M. Ghazawi, Michelle Le, François Lagacé, Janelle Cyr, Nebras Alghazawi, Andrei Zubarev, Simon F. Roy, Elham Rahme, Elena Netchiporouk, Osama Roshdy, Steven J. Glassman, Denis Sasseville, and Ivan V. Litvinov (2019).
Incidence, mortality and spatiotemporal distribution of cutaneous malignant melanoma cases across Canada
Journal of Cutaneous Medicine and Surgery , 394-412
Feras M. Ghazawi and Ivan V. Litvinov (2018).
Distribution and clustering of cutaneous t-cell lymphoma (CTCL) cases in Canada: A response to a letter
Journal of Cutaneous Medicine and Surgery , 657-658
François Lagacé, Feras M. Ghazawi, Michelle Le, Evgeny Savin, Andrei Zubarev, Mathieu Powell, Linda Moreau, Denis Sasseville, Ioana Popa, and Ivan V. Litvinov (2020).
Penile invasive squamous cell carcinoma: Analysis of incidence, mortality trends, and geographic distribution in Canada
Journal of Cutaneous Medicine and Surgery , 124-128
Elena Netchiporouk, Jennifer Gantchev, Matthew Tsang, Philippe Thibault, Andrew K. Watters, John-Douglas Matthew Hughes, Feras M. Ghazawi, Anders Woetmann, Niels Ødum, Denis Sasseville, and Ivan V. Litvinov (2017).
Analysis of CTCL cell lines reveals important differences between mycosis fungoides/Sézary syndrome vs. HTLV-1+ leukemic cell lines
Oncotarget , 95981-95998
Simon F. Roy, Feras M. Ghazawi, Michelle Le, François Lagacé, Catherine F. Roy, Elham Rahme, Evgeny Savin, Andrei Zubarev, Denis Sasseville, Gizelle Popradi, and Ivan V. Litvinov (2020).
Epidemiology of adult and pediatric Burkitt Lymphoma in Canada: Sequelae of the HIV epidemic
Current Oncology , 83-89
Feras M. Ghazawi, Michelle Le, Nebras Alghazawi, Elham Rahme, Linda Moreau, Elena Netchiporouk, Andrei Zubarev, Osama Roshdy, Steven J. Glassman, Denis Sasseville, and Ivan V. Litvinov (2019).
Trends in incidence of cutaneous malignant melanoma in Canada: 1992-2010 versus 2011-2015
Journal of the American Academy of Dermatology , 1157-1159
Feras M. Ghazawi, Rami Darwich, Michelle Le, Elham Rahme, Andrei Zubarev, Linda Moreau, Julia Valdemarin Burnier, Denis Sasseville, Miguel N. Burnier Jr., and Ivan V. Litvinov (2019).
Uveal melanoma incidence trends in Canada: A national comprehensive population-based study
British Journal of Ophthalmology , 1872-1876