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Abstract Introduction Alcohol contributes significantly global disease burden. Over 50 countries, including Canada, have established low?risk drinking guidelines to reduce alcohol?related harm. Canada’s Guidance on Alcohol and Health (CGAH) was released in 2023. This study examines the relationship between weekly alcohol consumption, CGAH risk zones and mortality patterns among Canadian drinkers aged 15 and older. Methods A retrospective cohort study was conducted using data from three cycles of the national, population?based Canadian Community Health Survey (2000–2006) linked to mortality data up to 2017. The sample included 145,760 respondents aged 15 and older who reported alcohol consumption in the past week. Average weekly alcohol consumption was assessed using the Timeline Followback method (i.e., 7?day recall). Outcomes included all?cause mortality, alcohol?related mortality and mortality from conditions with an alcohol?attributable fraction ?15%. Results Alcohol consumption was significantly positively associated with increased risks of all?cause (hazard ratio?=?1.01, p ?